PNKP

Across TCGA patient cohorts, PNKP RNA expression is significantly associated with the protein abundance of many other proteins, with 10,478 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PNKP-associated proteins across cancer lineages are TOM1L2, RUVBL1, and RUVBL2. Each is linked with PNKP in more than 4 cancer types. Because this analysis shows association rather than direction, both PNKP-to-partner and partner-to-PNKP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNKP versus TOM1L2 in HNSC, with a Pearson correlation of -0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKP→partner) and Y-score (partner→PNKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOM1L2 →	-0.498	-0.595	<.001	<.001	3	5
GBM	RUVBL1 →	+0.313	+0.335	.003	.008	3	4
GBM	RUVBL2 →	+0.363	+0.426	<.001	<.001	3	4
LUAD	MVB12A_S170 →	-0.640	-0.328	<.001	.003	3	4
LUAD	PRPF4B_S294 →	+0.721	+0.366	<.001	.002	3	4
COAD	BCAS1 →	-0.989	-0.563	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,478 associations by consensus.

PNKP vs TOM1L2 — HNSC

Explore this scatter interactively →