PNKP

Across TCGA patient cohorts, PNKP protein abundance is significantly associated with the RNA expression of many other genes, with 12,304 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNKP-associated genes across cancer lineages are ZSCAN22, NUP62, and PPP5C. Each is linked with PNKP in more than 6 cancer types. Because this analysis shows association rather than direction, both PNKP-to-partner and partner-to-PNKP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNKP versus ZSCAN22 in OV, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKP→partner) and Y-score (partner→PNKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZSCAN22 →	+0.630	+0.279	.001	<.001	3	7
OV	NUP62 →	+0.645	+0.288	.001	.001	3	7
OV	PPP5C →	+0.617	+0.268	<.001	.003	3	7
OV	ERVK3-1 →	+0.555	+0.291	.005	.001	3	7
LSCC	ZNF473 →	+0.604	+0.281	<.001	<.001	3	7
BRCA	FUZ →	+0.954	+0.396	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,304 associations by consensus.

PNKP vs ZSCAN22 — OV

Explore this scatter interactively →