PNKP

Across TCGA patient cohorts, PNKP mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNKP-associated genes across cancer lineages are A-Raf_pS299, ERK2, and Fibronectin. Each is linked with PNKP in more than 1 cancer types. Because this analysis shows association rather than direction, both PNKP-to-partner and partner-to-PNKP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PNKP-low versus PNKP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKP→partner) and Y-score (partner→PNKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.165	-3.459	.001	.005	3	1
UCEC	ERK2 →	+0.268	+3.700	.001	.001	3	1
UCEC	Fibronectin →	-0.370	-2.690	.008	.006	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.431	+2.321	.017	.033	3	1
UCEC	Heregulin →	-0.137	-2.000	.008	.030	3	1
UCEC	Ku80 →	+0.211	+3.013	.035	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

A-Raf_pS299 by PNKP expression — UCEC

Explore this box plot interactively →