PNKP

Across TCGA cell cohorts, PNKP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,317 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PNKP-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, mRNA alternative polyadenylation, and DNA replication proofreading. Each is linked with PNKP in more than 15 cancer types. Because this analysis shows association rather than direction, both PNKP-to-partner and partner-to-PNKP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by PNKP-low versus PNKP-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKP→partner) and Y-score (partner→PNKP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of calcium ion export across plasma membrane →	+0.087	+1.033	<.001	<.001	3	16
BONE	mRNA alternative polyadenylation →	+0.096	+1.001	.001	<.001	3	15
BONE	DNA replication proofreading →	+0.259	+1.103	<.001	<.001	3	14
BONE	Viral transcription →	+0.130	+1.075	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.141	+1.081	.001	.001	3	14
CNS	Oxidative demethylation →	-0.241	-0.781	.006	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,317 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by PNKP expression — BONE

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