PNKD

Across TCGA pan-cancer cohorts, PNKD Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PNKD data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PNKD Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PNKD expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SCLC, and SKCM are the cancer types where PNKD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.483	.022	22	view →
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
SKCM	OS	Median	All	0.113	0.327	.009	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PNKD–UCEC (DFS)

Open the UCEC breakdown →