PNKD

Across TCGA pan-cancer cohorts, PNKD mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PNKD data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PNKD mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PNKD expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where PNKD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.918	.012	42	view →
CCRCC	DFS	Quartile	III,IV	0.233	0.836	<.001	35	view →
PDAC	OS	Quartile	II,III,IV	0.926	0.689	.001	18	view →
LSCC	OS	Tertile	III,IV	0.916	0.613	.042	2	view →
GBM	OS	Quartile	All	0.379	0.607	.042	2	view →
LUAD	OS	Median	All	0.887	0.999	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PNKD–COAD (DFS)

Open the COAD breakdown →