PNKD

Across TCGA patient cohorts, PNKD mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNKD-associated genes across cancer lineages are ERK2, ETS-1, and GATA6. Each is linked with PNKD in more than 1 cancer types. Because this analysis shows association rather than direction, both PNKD-to-partner and partner-to-PNKD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PNKD-low versus PNKD-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKD→partner) and Y-score (partner→PNKD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ERK2 →	+0.273	+2.824	.012	.034	3	2
UCEC	ETS-1 →	+0.267	+2.321	.032	.034	3	2
UCEC	GATA6 →	-0.192	-3.307	.001	.009	3	2
SKCM	Mre11 →	-0.193	-3.144	.010	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.735	+1.584	.001	.036	3	2
UCEC	4E-BP1 →	+0.337	+3.730	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ERK2 by PNKD expression — SKCM

Explore this box plot interactively →