PNKD

Across TCGA cell cohorts, PNKD RNA expression is significantly associated with the go_rna of many other GO terms, with 2,840 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PNKD-associated GO terms across cancer lineages are Mitochondrial translational elongation, Cellular response to toxic substance, and Short-chain fatty acid metabolic process. Each is linked with PNKD in more than 8 cancer types. Because this analysis shows association rather than direction, both PNKD-to-partner and partner-to-PNKD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial translational elongation grouped by PNKD-low versus PNKD-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKD→partner) and Y-score (partner→PNKD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mitochondrial translational elongation →	+0.105	+1.230	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Cellular response to toxic substance →	+0.080	+0.585	<.001	<.001	3	8
BLOOD_Leukemia	Short-chain fatty acid metabolic process →	+0.112	+0.597	<.001	<.001	2	9
PANCREAS	Methylglyoxal metabolic process →	+0.082	+0.427	.006	.007	3	7
LARGE_INTESTINE	Glycoside metabolic process →	+0.098	+0.526	.006	.006	3	7
BREAST	Mitochondrial transport →	+0.085	+0.642	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,840 associations by consensus.

Mitochondrial translational elongation by PNKD expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →