PNKD

Across TCGA cell cohorts, PNKD mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PNKD-associated genes across cancer lineages are CRYBB1, OR6V1, and ITGAD. Each is linked with PNKD in more than 1 cancer types. Because this analysis shows association rather than direction, both PNKD-to-partner and partner-to-PNKD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by PNKD-low versus PNKD-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNKD→partner) and Y-score (partner→PNKD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CRYBB1 →	+0.019	+5.000	<.001	.006	3	1
PANCREAS	OR6V1 →	+0.022	+5.000	<.001	.006	3	1
LARGE_INTESTINE	ITGAD →	+0.015	+4.095	<.001	.009	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1
SKIN	EPB42 →	+0.021	+4.196	.006	.002	3	1
LUNG_NSCLC_LUAD	SPRR2G →	+0.096	+2.896	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CRYBB1 by PNKD expression — PANCREAS

Explore this box plot interactively →