PNISR

Across TCGA pan-cancer cohorts, PNISR Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PNISR data layer compared with 26 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PNISR Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PNISR expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

HNSC, LUSC, and LIHC are the cancer types where PNISR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.057	0.757	<.001	36	view →
LUSC	OS	Median	All	0.081	0.818	<.001	6	view →
LIHC	OS	Median	All	0.098	0.774	.001	6	view →
UCEC	DFS	Median	II,III,IV	0.915	0.438	.031	6	view →
LUAD	DFS	Median	All	0.244	0.767	.028	3	view →
SKCM	DFS	Median	All	0.996	0.730	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PNISR–HNSC (OS)

Open the HNSC breakdown →