PNISR

Across TCGA pan-cancer cohorts, PNISR mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PNISR data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PNISR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PNISR expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where PNISR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.539	0.821	.001	52	view →
PDAC	DFS	Tertile	All	0.907	0.649	.007	24	view →
LUAD	OS	Median	All	1.000	0.766	.004	18	view →
LSCC	DFS	Tertile	All	1.000	0.528	.004	9	view →
GBM	OS	Quartile	All	0.679	0.233	.012	7	view →
CCRCC	DFS	Median	All	0.638	0.820	.036	3	view →
UCEC	OS	Quartile	All	0.836	1.000	.011	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PNISR–HNSC (OS)

Open the HNSC breakdown →