PNISR

Across TCGA patient cohorts, PNISR protein abundance is significantly associated with the RNA expression of many other genes, with 12,762 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNISR-associated genes across cancer lineages are HDAC2, ORC3, and PHIP. Each is linked with PNISR in more than 5 cancer types. Because this analysis shows association rather than direction, both PNISR-to-partner and partner-to-PNISR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNISR versus HDAC2 in OV, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNISR→partner) and Y-score (partner→PNISR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HDAC2 →	+0.514	+0.334	.002	.004	3	6
OV	ORC3 →	+0.503	+0.315	<.001	<.001	2	6
LSCC	PHIP →	+0.464	+0.218	<.001	<.001	3	5
BRCA	TAF5 →	+0.486	+0.321	.001	.002	3	5
LSCC	POLR1C →	+0.392	+0.278	.006	<.001	3	5
BRCA	SNHG1 →	+0.749	+0.384	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,762 associations by consensus.

PNISR vs HDAC2 — OV

Explore this scatter interactively →