PNISR

Across TCGA patient cohorts, PNISR mutation is significantly associated with the RNA expression of many other genes, with 5,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNISR-associated genes across cancer lineages are EXOSC9, ZNHIT3, and RBBP4. Each is linked with PNISR in more than 4 cancer types. Because this analysis shows association rather than direction, both PNISR-to-partner and partner-to-PNISR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC9 grouped by PNISR-low versus PNISR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNISR→partner) and Y-score (partner→PNISR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EXOSC9 →	+0.434	+2.399	<.001	<.001	3	5
UCEC	ZNHIT3 →	+0.522	+2.776	<.001	<.001	3	4
UCEC	RBBP4 →	+0.491	+2.069	<.001	<.001	3	4
UCEC	MAD2L1 →	+0.769	+2.399	<.001	<.001	3	4
UCEC	TIPIN →	+0.407	+2.776	<.001	<.001	3	4
UCEC	SHMT2 →	+0.740	+2.684	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,031 associations by consensus.

EXOSC9 by PNISR expression — UCEC

Explore this box plot interactively →