PNISR

Across TCGA patient cohorts, PNISR mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNISR-associated genes across cancer lineages are eIF4E, MEK1, and Notch1. Each is linked with PNISR in more than 1 cancer types. Because this analysis shows association rather than direction, both PNISR-to-partner and partner-to-PNISR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PNISR-low versus PNISR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNISR→partner) and Y-score (partner→PNISR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.152	+1.662	.041	.011	3	2
UCEC	MEK1 →	+0.307	+1.362	.017	.037	3	2
UCEC	Notch1 →	+0.163	+2.598	.001	.005	3	2
UCEC	p27_pT198 →	+0.116	+3.700	.002	.001	3	2
COAD	Caspase-7-cleavedD198 →	+1.321	+3.008	.001	.019	3	2
UCEC	Caspase-8 →	-0.266	-2.392	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eIF4E by PNISR expression — UCEC

Explore this box plot interactively →