PNISR

Across TCGA cell cohorts, PNISR RNA expression is significantly associated with the go_rna of many other GO terms, with 4,165 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PNISR-associated GO terms across cancer lineages are Regulation of alternative mRNA splicing, via spliceosome, Termination of RNA polymerase II transcription, and Regulation of DNA-templated transcription initiation. Each is linked with PNISR in more than 16 cancer types. Because this analysis shows association rather than direction, both PNISR-to-partner and partner-to-PNISR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of alternative mRNA splicing, via spliceosome grouped by PNISR-low versus PNISR-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PNISR→partner) and Y-score (partner→PNISR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of alternative mRNA splicing, via spliceosome →	+0.093	+1.010	<.001	<.001	3	17
OESOPHAGUS	Termination of RNA polymerase II transcription →	+0.123	+1.031	.001	.006	3	17
OESOPHAGUS	Regulation of DNA-templated transcription initiation →	+0.061	+0.896	.002	<.001	3	16
BONE	Regulation of telomere maintenance →	+0.074	+1.091	.002	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.089	+1.245	<.001	<.001	3	16
BONE	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.191	+1.320	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,165 associations by consensus.

Regulation of alternative mRNA splicing, via spliceosome by PNISR expression — BONE

Explore this box plot interactively →