PNCK

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PNCK protein abundance is significantly associated with the RNA expression of many other genes, with 3,717 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PNCK-associated genes across cancer lineages are TNR, PTH2R, and ZNF274. Each is linked with PNCK in more than 1 cancer types. Because this analysis shows association rather than direction, both PNCK-to-partner and partner-to-PNCK results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PNCK versus TNR in GBM, with a Pearson correlation of 0.41.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNCK→partner) and Y-score (partner→PNCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMTNR →+1.797+0.558<.001<.00132
UCECPTH2R →+1.490+0.723.005.00632
UCECZNF274 →-1.049-0.723<.001.00632
UCECWASIR1 →+0.700+0.723.004.00632
UCECRN7SL508P →+1.193+0.723.001.00632
UCECMIR4479 →-2.893-0.723<.001.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,717 associations by consensus.

PNCK vs TNR — GBM

Per-sample scatter of PNCK vs TNR in GBM (Pearson r = 0.41).

Explore this scatter interactively →

Exploration