PNCK

Across TCGA patient cohorts, PNCK mutation is significantly associated with the RNA expression of many other genes, with 4,613 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNCK-associated genes across cancer lineages are LINC01309, LINC02165, and ADO. Each is linked with PNCK in more than 1 cancer types. Because this analysis shows association rather than direction, both PNCK-to-partner and partner-to-PNCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01309 grouped by PNCK-low versus PNCK-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNCK→partner) and Y-score (partner→PNCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	LINC01309 →	+0.064	+7.962	<.001	.007	3	2
BLCA	LINC02165 →	+0.100	+4.289	<.001	.007	3	2
UCEC	ADO →	+0.323	+2.032	.006	.001	3	2
UCEC	GTF2H2C →	+0.334	+1.752	<.001	<.001	3	2
UCEC	LIN9 →	+0.443	+1.709	.002	<.001	3	2
UCEC	MAPK11 →	+0.682	+2.066	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,613 associations by consensus.

LINC01309 by PNCK expression — THCA

Explore this box plot interactively →