PNCK

Across TCGA patient cohorts, PNCK mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PNCK-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and GAPDH. Each is linked with PNCK in more than 1 cancer types. Because this analysis shows association rather than direction, both PNCK-to-partner and partner-to-PNCK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PNCK-low versus PNCK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PNCK→partner) and Y-score (partner→PNCK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.124	-2.502	<.001	.001	3	2
UCEC	FOXO3a_pS318_S321 →	-0.086	-1.312	.027	.027	3	2
UCEC	GAPDH →	+0.336	+1.584	.043	.032	3	2
UCEC	p62 Lck ligand →	+0.405	+1.935	<.001	.002	3	2
UCEC	PDK1_pS241 →	+0.163	+1.847	.002	.007	3	2
UCEC	Shc_pY317 →	-0.184	-3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

A-Raf_pS299 by PNCK expression — UCEC

Explore this box plot interactively →