PMVK

Across TCGA pan-cancer cohorts, PMVK mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PMVK’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PMVK mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PMVK is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and PDAC are the cancer types where PMVK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PMVK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−0.635	<.001	11	view →
HNSC	Male	All	−0.208	.001	8	view →
PDAC	Male	All	+1.019	<.001	7	view →
CCRCC	Male	III,IV	+0.379	<.001	6	view →
LUAD	Female	All	+0.304	<.001	6	view →
LSCC	Male	II,III,IV	+0.229	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PMVK–COAD

Open the COAD breakdown →