PMVK

Across TCGA patient cohorts, PMVK mutation is significantly associated with the RNA expression of many other genes, with 466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMVK-associated genes across cancer lineages are IGKV3D-31, RN7SL643P, and EIF1AXP2. Each is linked with PMVK in more than 1 cancer types. Because this analysis shows association rather than direction, both PMVK-to-partner and partner-to-PMVK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV3D-31 grouped by PMVK-low versus PMVK-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMVK→partner) and Y-score (partner→PMVK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IGKV3D-31 →	+0.161	+5.812	<.001	.003	3	2
HNSC	RN7SL643P →	+0.122	+4.655	.001	.007	3	2
HNSC	EIF1AXP2 →	+0.156	+4.565	.008	.004	3	2
HNSC	MIR3173 →	+0.559	+4.748	<.001	.003	3	2
HNSC	SNORA11B →	+0.508	+4.295	<.001	.008	3	2
UCEC	RNA5SP413 →	+1.418	+2.540	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 466 associations by consensus.

IGKV3D-31 by PMVK expression — CESC

Explore this box plot interactively →