PMVK

Across TCGA patient cohorts, PMVK mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMVK-associated genes across cancer lineages are PCNA, PRDX1, and VHL. Each is linked with PMVK in more than 1 cancer types. Because this analysis shows association rather than direction, both PMVK-to-partner and partner-to-PMVK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PMVK-low versus PMVK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMVK→partner) and Y-score (partner→PMVK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.241	+3.321	.033	.010	3	1
UCEC	PRDX1 →	+0.310	+2.999	.004	.035	3	1
UCEC	VHL →	-0.781	-3.000	.028	.036	3	1
UCEC	ATM →	-0.556	-3.321	.019	.010	3	1
UCEC	Cyclin-B1 →	+0.632	+3.321	.031	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PCNA by PMVK expression — UCEC

Explore this box plot interactively →