PMS2

Across TCGA patient cohorts, PMS2 mutation is significantly associated with the RNA expression of many other genes, with 5,549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMS2-associated genes across cancer lineages are RBX1, PHF5A, and EIF2B2. Each is linked with PMS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PMS2-to-partner and partner-to-PMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBX1 grouped by PMS2-low versus PMS2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS2→partner) and Y-score (partner→PMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RBX1 →	+0.416	+2.925	<.001	<.001	3	3
UCEC	PHF5A →	+0.602	+3.954	<.001	<.001	3	3
UCEC	EIF2B2 →	+0.392	+2.627	<.001	<.001	3	3
SKCM	UBE2M →	+0.429	+3.762	<.001	<.001	3	3
COAD	TOE1 →	+0.451	+3.183	.001	.009	3	3
UCEC	LDHA →	+0.634	+1.893	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,549 associations by consensus.

RBX1 by PMS2 expression — SKCM

Explore this box plot interactively →