PMS2

Across TCGA patient cohorts, PMS2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMS2-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and MEK1. Each is linked with PMS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PMS2-to-partner and partner-to-PMS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PMS2-low versus PMS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS2→partner) and Y-score (partner→PMS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.240	+2.584	.001	.010	3	3
COAD	Caspase-7-cleavedD198 →	+1.325	+3.008	.001	.019	3	3
UCEC	MEK1 →	+0.396	+2.523	.001	<.001	3	2
UCEC	Akt_pT308 →	+0.433	+1.700	.043	.040	3	2
UCEC	Shc_pY317 →	-0.114	-1.514	.027	.015	3	2
UCEC	ASNS →	+0.411	+1.415	<.001	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

PCNA by PMS2 expression — UCEC

Explore this box plot interactively →