PMS1

Across TCGA patient cohorts, PMS1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMS1-associated genes across cancer lineages are ATM, eIF4E, and INPP4B. Each is linked with PMS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PMS1-to-partner and partner-to-PMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PMS1-low versus PMS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS1→partner) and Y-score (partner→PMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.421	-2.321	.011	.034	3	3
UCEC	eIF4E →	+0.208	+2.736	.007	<.001	3	2
UCEC	INPP4B →	-0.240	-2.459	.043	.018	3	2
UCEC	PCNA →	+0.190	+1.502	.016	.030	3	2
UCEC	Rab25 →	-0.336	-1.502	.005	.030	3	2
UCEC	VHL →	-0.913	-2.087	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by PMS1 expression — UCEC

Explore this box plot interactively →