PMS1

Across TCGA cell cohorts, PMS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,733 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PMS1-associated GO terms across cancer lineages are Mismatch repair, Replication fork processing, and DNA-templated DNA replication. Each is linked with PMS1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PMS1-to-partner and partner-to-PMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mismatch repair grouped by PMS1-low versus PMS1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS1→partner) and Y-score (partner→PMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Mismatch repair →	+0.103	+1.003	<.001	<.001	3	20
SOFT_TISSUE	Replication fork processing →	+0.086	+0.688	<.001	<.001	3	19
PANCREAS	DNA-templated DNA replication →	+0.103	+0.555	.005	.005	3	18
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.112	+1.105	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Telomere maintenance →	+0.087	+1.134	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.113	+1.028	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,733 associations by consensus.

Mismatch repair by PMS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →