PMS1

Across TCGA cell cohorts, PMS1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PMS1-associated genes across cancer lineages are BANF2, C12orf40, and USP17L3. Each is linked with PMS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMS1-to-partner and partner-to-PMS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BANF2 grouped by PMS1-low versus PMS1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMS1→partner) and Y-score (partner→PMS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BANF2 →	+0.042	+4.058	<.001	.009	3	2
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	2
CNS	USP17L3 →	+0.006	+5.044	.001	.001	3	1
LARGE_INTESTINE	AMELX →	+0.404	+2.662	.004	.007	3	1
LARGE_INTESTINE	STOML3 →	+0.224	+3.392	<.001	.003	3	1
LARGE_INTESTINE	MS4A3 →	+0.104	+3.478	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

BANF2 by PMS1 expression — BLOOD_Lymphoma

Explore this box plot interactively →