PMPCA

Across TCGA patient cohorts, PMPCA mutation is significantly associated with the RNA expression of many other genes, with 1,701 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMPCA-associated genes across cancer lineages are RNA5SP453, OR51G1, and STOML2. Each is linked with PMPCA in more than 2 cancer types. Because this analysis shows association rather than direction, both PMPCA-to-partner and partner-to-PMPCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP453 grouped by PMPCA-low versus PMPCA-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMPCA→partner) and Y-score (partner→PMPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP453 →	+0.197	+3.891	<.001	.002	3	3
BRCA	OR51G1 →	+0.034	+7.731	<.001	.009	3	2
UCEC	STOML2 →	+0.456	+3.502	.005	.002	3	2
UCEC	IGF2 →	-2.050	-3.076	<.001	<.001	3	2
UCEC	TOMM5 →	+0.666	+3.839	<.001	<.001	3	2
SKCM	DNM1P38 →	+0.107	+2.587	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,701 associations by consensus.

RNA5SP453 by PMPCA expression — CESC

Explore this box plot interactively →