PMPCA

Across TCGA patient cohorts, PMPCA mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMPCA-associated genes across cancer lineages are VHL, eEF2, and GAPDH. Each is linked with PMPCA in more than 1 cancer types. Because this analysis shows association rather than direction, both PMPCA-to-partner and partner-to-PMPCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by PMPCA-low versus PMPCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMPCA→partner) and Y-score (partner→PMPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-1.289	-2.584	<.001	.010	3	2
UCEC	eEF2 →	+0.394	+2.000	.014	.032	3	1
UCEC	GAPDH →	+0.587	+2.700	.015	.006	3	1
UCEC	ACVRL1 →	-0.175	-2.000	.004	.032	3	1
UCEC	MEK1 →	+0.488	+3.169	.003	.018	3	1
UCEC	N-Ras →	-0.128	-1.986	.017	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

VHL by PMPCA expression — UCEC

Explore this box plot interactively →