PMPCA

Across TCGA cell cohorts, PMPCA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,700 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PMPCA-associated GO terms across cancer lineages are Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and rRNA 5'-end processing. Each is linked with PMPCA in more than 15 cancer types. Because this analysis shows association rather than direction, both PMPCA-to-partner and partner-to-PMPCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by PMPCA-low versus PMPCA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMPCA→partner) and Y-score (partner→PMPCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.153	+0.628	.004	.009	3	16
BONE	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.155	+0.786	<.001	.001	3	16
BONE	rRNA 5'-end processing →	+0.155	+0.786	<.001	.001	3	16
BONE	Nucleosome disassembly →	+0.190	+0.759	<.001	.002	3	15
PANCREAS	Transcription by RNA polymerase I →	+0.109	+1.267	<.001	<.001	3	15
BONE	Transcription initiation at RNA polymerase I promoter →	+0.143	+1.001	<.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,700 associations by consensus.

Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by PMPCA expression — BONE

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