PMP22

Across TCGA patient cohorts, PMP22 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMP22-associated genes across cancer lineages are A-Raf_pS299, Gab2, and Di-Ras3. Each is linked with PMP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMP22-to-partner and partner-to-PMP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by PMP22-low versus PMP22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMP22→partner) and Y-score (partner→PMP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.209	-3.584	<.001	.002	3	2
UCEC	Gab2 →	+0.427	+1.906	.002	.016	3	2
UCEC	Di-Ras3 →	-0.203	-2.415	<.001	.003	3	2
UCEC	eEF2 →	+0.347	+2.415	.015	.003	3	1
UCEC	EGFR_pY1068 →	-0.350	-3.807	<.001	<.001	3	1
UCEC	ERK2 →	+0.202	+3.321	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

A-Raf_pS299 by PMP22 expression — UCEC

Explore this box plot interactively →