PMP22

Across TCGA cell cohorts, PMP22 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,971 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PMP22-associated GO terms across cancer lineages are Positive regulation of focal adhesion assembly, Peptidyl-lysine oxidation, and Regulation of cell-substrate junction assembly. Each is linked with PMP22 in more than 13 cancer types. Because this analysis shows association rather than direction, both PMP22-to-partner and partner-to-PMP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of focal adhesion assembly grouped by PMP22-low versus PMP22-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMP22→partner) and Y-score (partner→PMP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of focal adhesion assembly →	+0.227	+3.714	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.443	+2.708	<.001	<.001	3	13
BONE	Regulation of cell-substrate junction assembly →	+0.167	+3.896	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Elastin metabolic process →	+0.327	+3.194	<.001	<.001	3	12
BONE	Regulation of focal adhesion assembly →	+0.167	+3.896	<.001	<.001	3	12
BONE	Positive regulation of cell-substrate junction organization →	+0.169	+3.218	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,971 associations by consensus.

Positive regulation of focal adhesion assembly by PMP22 expression — BONE

Explore this box plot interactively →