PMP22

Across TCGA cell cohorts, PMP22 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PMP22-associated genes across cancer lineages are AVP, CDX4, and VAX1. Each is linked with PMP22 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMP22-to-partner and partner-to-PMP22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by PMP22-low versus PMP22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMP22→partner) and Y-score (partner→PMP22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.041	+3.217	<.001	.006	3	1
LARGE_INTESTINE	CDX4 →	+0.007	+3.217	.001	.006	3	1
LARGE_INTESTINE	VAX1 →	+0.618	+3.519	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

AVP by PMP22 expression — LARGE_INTESTINE

Explore this box plot interactively →