PMIS2

Across TCGA cell cohorts, PMIS2 RNA expression is significantly associated with the mutation status of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PMIS2-associated genes across cancer lineages are TRIP11, OLFM4, and POP1. Each is linked with PMIS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMIS2-to-partner and partner-to-PMIS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIP11 grouped by PMIS2-low versus PMIS2-high in LUNG_NSCLC_LUAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMIS2→partner) and Y-score (partner→PMIS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIP11 →	+5.228	+0.045	.005	<.001	3	1
LUNG_NSCLC_LUAD	OLFM4 →	+5.228	+0.045	.005	<.001	3	1
LUNG_NSCLC_LUAD	POP1 →	+3.006	+0.016	.005	<.001	3	1
LUNG_NSCLC_LUAD	RNF130 →	+5.228	+0.038	.005	<.001	3	1
LUNG_NSCLC_LUAD	NT5C1A →	+5.228	+0.038	.005	<.001	3	1
LUNG_NSCLC_LUAD	GRIA2 →	+3.228	+0.018	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

TRIP11 by PMIS2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →