PMFBP1

Across TCGA patient cohorts, PMFBP1 mutation is significantly associated with the RNA expression of many other genes, with 3,852 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMFBP1-associated genes across cancer lineages are SHCBP1, RNU6-716P, and NDUFA12. Each is linked with PMFBP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PMFBP1-to-partner and partner-to-PMFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHCBP1 grouped by PMFBP1-low versus PMFBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMFBP1→partner) and Y-score (partner→PMFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SHCBP1 →	+0.670	+3.917	<.001	<.001	3	4
LIHC	RNU6-716P →	+0.373	+5.544	<.001	.004	3	3
LUAD	NDUFA12 →	+0.425	+3.227	.001	.009	3	3
UCEC	OIP5 →	+0.807	+2.021	<.001	<.001	3	3
UCEC	LRRC59 →	+0.484	+2.255	<.001	.001	3	3
SKCM	ITGB1BP1 →	+0.352	+1.572	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,852 associations by consensus.

SHCBP1 by PMFBP1 expression — UCEC

Explore this box plot interactively →