PMFBP1

Across TCGA patient cohorts, PMFBP1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMFBP1-associated genes across cancer lineages are PCNA, c-Jun_pS73, and GAPDH. Each is linked with PMFBP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PMFBP1-to-partner and partner-to-PMFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PMFBP1-low versus PMFBP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMFBP1→partner) and Y-score (partner→PMFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.273	+2.459	<.001	<.001	3	3
SKCM	c-Jun_pS73 →	-0.130	-1.760	.003	.002	3	3
SKCM	GAPDH →	+0.633	+1.777	<.001	.002	3	3
UCEC	INPP4B →	-0.221	-2.222	.048	.009	3	2
UCEC	JNK_pT183_Y185 →	-0.206	-2.807	<.001	.002	3	2
UCEC	MEK1 →	+0.443	+3.087	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

PCNA by PMFBP1 expression — UCEC

Explore this box plot interactively →