PMFBP1

Across TCGA cell cohorts, PMFBP1 mutation is significantly associated with the RNA expression of many other genes, with 299 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PMFBP1-associated genes across cancer lineages are SPO11, CD300LD, and IL4. Each is linked with PMFBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMFBP1-to-partner and partner-to-PMFBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPO11 grouped by PMFBP1-low versus PMFBP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMFBP1→partner) and Y-score (partner→PMFBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPO11 →	+0.017	+4.969	<.001	.003	3	2
OESOPHAGUS	CD300LD →	+0.013	+4.906	<.001	.006	3	1
LUNG_SCLC	IL4 →	+0.108	+3.232	.003	.008	3	1
LUNG_SCLC	CLPSL1 →	+0.339	+3.750	<.001	.003	3	1
BREAST	LCN9 →	+0.079	+5.169	<.001	.005	3	1
BREAST	OR1L3 →	+0.019	+5.169	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 299 associations by consensus.

SPO11 by PMFBP1 expression — BLOOD_Leukemia

Explore this box plot interactively →