PMF1

Across TCGA patient cohorts, PMF1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMF1-associated genes across cancer lineages are eEF2, TIGAR, and p62 Lck ligand. Each is linked with PMF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMF1-to-partner and partner-to-PMF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PMF1-low versus PMF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMF1→partner) and Y-score (partner→PMF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.427	+3.000	.039	.037	3	1
UCEC	TIGAR →	+0.174	+3.026	.049	.019	3	1
UCEC	p62 Lck ligand →	+0.450	+2.817	.016	.036	2	1
UCEC	Shc_pY317 →	-0.184	-3.000	.036	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

eEF2 by PMF1 expression — UCEC

Explore this box plot interactively →