PMEPA1

Across TCGA patient cohorts, PMEPA1 mutation is significantly associated with the RNA expression of many other genes, with 1,573 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMEPA1-associated genes across cancer lineages are RNA5SP419, PHKG1, and LETM1. Each is linked with PMEPA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PMEPA1-to-partner and partner-to-PMEPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP419 grouped by PMEPA1-low versus PMEPA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMEPA1→partner) and Y-score (partner→PMEPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP419 →	+0.448	+1.977	.002	.004	3	3
UCEC	PHKG1 →	+0.253	+2.702	.007	.004	3	2
UCEC	LETM1 →	+0.473	+2.338	<.001	.003	3	2
UCEC	KCNG1 →	-1.175	-2.662	<.001	<.001	3	2
UCEC	MAP3K9 →	+0.595	+2.963	<.001	<.001	3	2
SKCM	RNU6-1264P →	+0.100	+3.993	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,573 associations by consensus.

RNA5SP419 by PMEPA1 expression — UCEC

Explore this box plot interactively →