PMEPA1

Across TCGA cell cohorts, PMEPA1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PMEPA1-associated genes across cancer lineages are PNMA3, CFHR2, and ASB17. Each is linked with PMEPA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMEPA1-to-partner and partner-to-PMEPA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNMA3 grouped by PMEPA1-low versus PMEPA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMEPA1→partner) and Y-score (partner→PMEPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNMA3 →	+0.164	+3.781	<.001	.003	3	1
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	1
SKIN	ASB17 →	+0.019	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PNMA3 by PMEPA1 expression — LARGE_INTESTINE

Explore this box plot interactively →