Across TCGA patient cohorts, PMCH RNA expression is significantly associated with the go_rna of many other GO terms, with 7,016 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PMCH-associated GO terms across cancer lineages are B cell receptor signaling pathway, Regulation of tolerance induction, and CD4-positive, alpha-beta T cell differentiation. Each is linked with PMCH in more than 20 cancer types. Because this analysis shows association rather than direction, both PMCH-to-partner and partner-to-PMCH results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMCH→partner) and Y-score (partner→PMCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	B cell receptor signaling pathway →	+0.092	+0.646	.003	.004	3	21
THYM	Regulation of tolerance induction →	+0.072	+0.598	<.001	<.001	3	21
THCA	CD4-positive, alpha-beta T cell differentiation →	+0.044	+0.420	<.001	<.001	3	20
CHOL	Regulation of lymphocyte differentiation →	+0.046	+0.490	<.001	.006	2	21
CHOL	Negative regulation of cell activation →	+0.044	+0.637	.002	.004	3	20
CHOL	Cell adhesion mediated by integrin →	+0.076	+0.373	.003	.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,016 associations by consensus.

Exploration

PMCH survival (RNA) · tumor vs normal (RNA) · all PMCH data types