Across TCGA patient cohorts, PMCH mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PMCH-associated genes across cancer lineages are OR51G1, CTHRC1P1, and RN7SKP221. Each is linked with PMCH in more than 1 cancer types. Because this analysis shows association rather than direction, both PMCH-to-partner and partner-to-PMCH results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMCH→partner) and Y-score (partner→PMCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR51G1 →	+0.059	+7.731	<.001	.009	3	1
UCEC	CTHRC1P1 →	+0.241	+4.694	<.001	.007	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1
BRCA	TSPY10 →	+0.034	+7.731	<.001	.009	3	1
SKCM	ATP13A5-AS1 →	+1.065	+4.235	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

PMCH survival (RNA) · tumor vs normal (RNA) · all PMCH data types