PM20D2

Across TCGA pan-cancer cohorts, PM20D2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PM20D2 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PM20D2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PM20D2 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and HNSC are the cancer types where PM20D2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.905	0.648	<.001	64	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.268	.003	26	view →
HNSC	OS	Quartile	II,III,IV	0.774	0.975	.007	12	view →
PDAC	DFS	Median	All	0.482	0.249	.007	9	view →
GBM	DFS	Quartile	All	0.433	0.232	.025	4	view →
LUAD	DFS	Quartile	II,III,IV	0.248	0.687	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PM20D2–LSCC (DFS)

Open the LSCC breakdown →