PM20D2

Across TCGA cell cohorts, PM20D2 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PM20D2-associated genes across cancer lineages are EPPIN, OR9K2, and NKX2-6. Each is linked with PM20D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PM20D2-to-partner and partner-to-PM20D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPPIN grouped by PM20D2-low versus PM20D2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PM20D2→partner) and Y-score (partner→PM20D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	OR9K2 →	+0.012	+5.539	.007	.003	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	ARSH →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	USP17L20 →	+0.006	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EPPIN by PM20D2 expression — BLOOD_Leukemia

Explore this box plot interactively →