PLXNC1

Across TCGA patient cohorts, PLXNC1 mutation is significantly associated with the RNA expression of many other genes, with 6,185 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNC1-associated genes across cancer lineages are C18orf25, AOC1, and LINC00471. Each is linked with PLXNC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLXNC1-to-partner and partner-to-PLXNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C18orf25 grouped by PLXNC1-low versus PLXNC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNC1→partner) and Y-score (partner→PLXNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C18orf25 →	+0.329	+1.747	<.001	.003	3	4
UCEC	AOC1 →	-1.439	-1.378	<.001	<.001	3	4
UCEC	LINC00471 →	+0.236	+1.432	.006	<.001	3	4
UCEC	EMID1 →	-0.924	-2.190	<.001	<.001	3	4
LUAD	ADNP2 →	+0.619	+3.602	<.001	.001	3	3
UCEC	SCO1 →	+0.571	+2.148	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,185 associations by consensus.

C18orf25 by PLXNC1 expression — UCEC

Explore this box plot interactively →