PLXNC1

Across TCGA patient cohorts, PLXNC1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PLXNC1-associated genes across cancer lineages are MIG-6, ATM, and Caspase-7-cleavedD198. Each is linked with PLXNC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXNC1-to-partner and partner-to-PLXNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by PLXNC1-low versus PLXNC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNC1→partner) and Y-score (partner→PLXNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.090	+3.644	.035	.001	3	3
COAD	ATM →	-0.708	-3.576	<.001	.002	3	3
COAD	Caspase-7-cleavedD198 →	+1.367	+3.016	<.001	.018	3	3
UCEC	EGFR_pY1068 →	-0.244	-2.201	<.001	<.001	3	3
UCEC	PRAS40_pT246 →	+0.100	+1.392	.027	.017	3	3
UCEC	Caveolin-1 →	-0.406	-1.584	.034	.015	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

MIG-6 by PLXNC1 expression — COAD

Explore this box plot interactively →