PLXNC1

Across TCGA cell cohorts, PLXNC1 mutation is significantly associated with the RNA expression of many other genes, with 760 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXNC1-associated genes across cancer lineages are C12orf40, TMEM132C, and CGB3. Each is linked with PLXNC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PLXNC1-to-partner and partner-to-PLXNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C12orf40 grouped by PLXNC1-low versus PLXNC1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNC1→partner) and Y-score (partner→PLXNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	C12orf40 →	+0.010	+4.444	<.001	.001	3	3
BLOOD_Leukemia	TMEM132C →	+0.489	+2.644	.001	.008	3	2
SKIN	CGB3 →	+0.158	+3.920	.007	.005	3	2
SKIN	OPN4 →	+0.049	+4.688	<.001	<.001	3	2
SKIN	IFITM5 →	+0.118	+3.807	<.001	.007	3	2
LARGE_INTESTINE	GPR63 →	+0.876	+2.000	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 760 associations by consensus.

C12orf40 by PLXNC1 expression — OVARY

Explore this box plot interactively →