PLXNC1

Across TCGA cell cohorts, PLXNC1 mutation is significantly associated with the mutation status of many other genes, with 6,263 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PLXNC1-associated genes across cancer lineages are MYH14, CADPS, and FBN2. Each is linked with PLXNC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PLXNC1-to-partner and partner-to-PLXNC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH14 grouped by PLXNC1-low versus PLXNC1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNC1→partner) and Y-score (partner→PLXNC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MYH14 →	+3.337	+2.969	.009	.009	1	7
OVARY	CADPS →	+3.345	+3.345	.007	.007	1	7
OVARY	FBN2 →	+3.345	+3.882	.001	.001	1	6
OVARY	ZNF609 →	+5.345	+4.632	<.001	<.001	1	6
BLOOD_Lymphoma	PRRC2B →	+3.752	+3.409	<.001	<.001	1	6
OVARY	CIC →	+3.082	+4.669	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,263 associations by consensus.

MYH14 by PLXNC1 expression — BLOOD_Lymphoma

Explore this box plot interactively →