Across TCGA patient cohorts, PLXNB3 mutation is significantly associated with the RNA expression of many other genes, with 7,564 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PLXNB3-associated genes across cancer lineages are NEIL3, CENPE, and EME1. Each is linked with PLXNB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PLXNB3-to-partner and partner-to-PLXNB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNB3→partner) and Y-score (partner→PLXNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NEIL3 →	+0.410	+3.901	<.001	<.001	3	5
COAD	CENPE →	+0.502	+1.936	<.001	.002	3	5
LUAD	EME1 →	+0.748	+2.700	.001	.006	3	5
UCEC	CIP2A →	+0.429	+1.115	.003	.004	3	5
COAD	CKAP2L →	+0.560	+2.013	<.001	<.001	3	5
COAD	EZH2 →	+0.350	+2.321	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,564 associations by consensus.

Exploration

PLXNB3 survival (RNA) · tumor vs normal (RNA) · all PLXNB3 data types