Across TCGA patient cohorts, PLXNB3 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PLXNB3-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and c-Kit. Each is linked with PLXNB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PLXNB3-to-partner and partner-to-PLXNB3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PLXNB3→partner) and Y-score (partner→PLXNB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.486	-1.700	<.001	.038	3	4
COAD	Caspase-7-cleavedD198 →	+1.152	+2.923	<.001	<.001	3	4
STAD	c-Kit →	-0.322	-3.169	.019	.018	3	3
COAD	GAPDH →	+0.383	+1.593	.019	.011	3	3
COAD	PCNA →	+0.186	+1.593	.020	.011	3	3
UCEC	Shc_pY317 →	-0.093	-0.906	.021	.041	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

Exploration

PLXNB3 survival (RNA) · tumor vs normal (RNA) · all PLXNB3 data types