Across TCGA pan-cancer cohorts, PLXNB2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PLXNB2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PLXNB2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PLXNB2 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where PLXNB2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PLXNB2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.188	<.001	10	view →
LUAD	Male	All	−0.173	<.001	7	view →
PDAC	All	II,III,IV	+0.189	<.001	6	view →
HNSC	All	All	−0.097	.016	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PLXNB2 RNA expression & survival · all PLXNB2 data types